YO-01027 ( Dibenzazepine )

Catalog No. M13326 CAS No. 209984-56-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

YO-01027
Note

Research use only, not for human use.
Brief Description

YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
Description

YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
In Vitro

YO-01027 (0.25-10 μM, during 1-18 days) promotes iPSC generation from human neonatal keratinocytes.YO-01027 (2 μM, 3 days) does not affect p53 activity in OCT4, SOX2-transduced human keratinocytes.YO-01027 (10 μM, 3 days) promotes the proliferation of supporting cells (SCs) in cultured mouse cochleae.YO-01027 (10 μM, 3 days) generates new hair cell (HCs) and increases the HCs number in neonatal mouse cochleae.
In Vivo

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Synonyms

Dibenzazepine
Pathway

Neuroscience
Target

Gamma-secretase
Recptor

γ secretase (APPL)| γ secretase(Notch)
Research Area

Metabolic Disease
Indication

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CAS Number

209984-56-5
Formula Weight

463.48
Molecular Formula

C26H23F2N3O3
Purity

>98% (HPLC)
Solubility

DMSO:92 mg/mL (198.49 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

C[C@H](NC(CC1=CC(F)=CC(F)=C1)=O)C(N[C@@H]2C(N(C)C3=CC=CC=C3C4=CC=CC=C24)=O)=O
Chemical Name

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

1.Groth C, et al, Mol Pharmacol, 2010, 77(4), 567-574.

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