Flovagatran

Research use only, not for human use.

Flovagatran (TGN 255) is an orally active, potent, and selective inhibitor of thrombin and parenteral direct factor II.Flovagatran is used to study venous thromboembolism.

Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis.

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Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs.Animal Model:Chicks Dosage:1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes.2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes.5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes.Administration:Bolus plus infusion Result:Elevated PD markers, and produced minimal post-operative blood loss.

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Autophagy

Thrombin

Thrombin

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871576-03-3

525.4

C27H36BN3O7

>98% (HPLC)

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C([C@@H](CC1=CC=CC=C1)NC(OCC2=CC=CC=C2)=O)(=O)N3[C@H](C(N[C@@H](CCCOC)B(O)O)=O)CCC3

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(-20℃)

With Ice Pack

≥ 2 years