Etamsylate

Research use only, not for human use.

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.

Cell Migration Assay Cell Line:HMEC-1 and HUVECs cells Concentration:0-100 μM Incubation Time:3-8 h Result:Didn’t affect the migration of HMEC-1 cells.Inhibited the migration of HUVECs cells.Thinned the morphology of the closed network and enlarged the closed cells.Western Blot Analysis Cell Line:HUVECs cells Concentration:0-100 μM Incubation Time:48 h Result:Decreased the amount of Akt1 phosphorylated.Decreased pERK2 levels at the highest doses (50-100 μM).

Animal Model:C57BL/6J female mice of spinal cord injury Dosage:100 mg/kg Administration:Oral gavage (p.o.), twice a day, three days Result:Attenuated the MMP-9 expression.Inhibited the degradation of TJ proteins.Reduced the upregulation of IL-1β, IL-6, and TNF-α.Reduced axonal demyelination and decreased cystic cavity formation.Reduced the extent of Fibrotic scar formation.

Ethamsylate | E 141 | MD 141 | Aglumin | Altodor | Eselin

Autophagy

Thrombin

Thrombopoiesis

Cardiovascular Disease

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2624-44-4

263.31

C10H17NO5S

>98% (HPLC)

Water: 53 mg/mL (201.28 mM); DMSO: 53 mg/mL (201.28 mM)

O=S(C1=CC(O)=CC=C1O)(O)=O.CCNCC

Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine

(-20℃)

With Ice Pack

≥ 2 years