RN9893( —— )

Catalog No. M34399 CAS No. 1803003-68-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RN9893
Note

Research use only, not for human use.
Brief Description

RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.
Description

RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.
In Vitro

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In Vivo

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Synonyms

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Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRP/TRPV Channel
Research Area

——
Indication

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CAS Number

1803003-68-0
Formula Weight

500.49
Molecular Formula

C21H23F3N4O5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (499.51 mM; Ultrasonic )
SMILES

C(NC1=CC=C(S(=O)(=O)N2CCN(C(C)C)CC2)C=C1)(=O)C3=C(N(=O)=O)C=C(C(F)(F)F)C=C3
Chemical Name

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1. Wei ZL, et, al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5.?

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