Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - M8-B Hydrochloride

M8-B Hydrochloride

CAS No. 883976-12-3

M8-B Hydrochloride( —— )

Catalog No. M21971 CAS No. 883976-12-3

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 65 In Stock
25MG 141 In Stock
50MG 221 In Stock
100MG 328 In Stock
200MG 458 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    M8-B Hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist.
  • Description
    M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions. M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures. M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Trpm8+/+ rats and mice Dosage:6 mg/kg Administration:I.v. or i.p.Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPM8
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    883976-12-3
  • Formula Weight
    432.96
  • Molecular Formula
    C22H25ClN2O3S?
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (577.42 mM)
  • SMILES
    Cl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zandi N , Zaniani N R , Moghimi A , et al. Protective effects of M8?B, a TRPM8 antagonist, on febrile? and pentylenetetrazol?induced seizures[J]. Acta neurobiologiae experimentalis, 2019, 79(1):86-91. 2. Almeida M C , Hew-Butler T , Soriano R N , et al. Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature[J]. Journal of Neuroscience, 2012, 32(6):2086-2099.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • PF-05105679

    PF-05105679 is a potent, selective TRPM8 channel inhibitor with IC50 of 103 nM (human TRPM8 currents inhibition).

  • Pinokalant

    Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region.

  • Linoleoyl Ethanolami...

    Linoleoyl Ethanolamide is an endocannabinoid agent.?It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.

Sign In Join Free