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Ispronicline
CAS No. 252870-53-4
Ispronicline( —— )
Catalog No. M34291 CAS No. 252870-53-4
Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 64 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 57 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 148 | In Stock |
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| 50MG | 206 | In Stock |
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| 100MG | 305 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIspronicline
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NoteResearch use only, not for human use.
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Brief DescriptionIspronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.
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DescriptionIspronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR.
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In Vitro——
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In VivoIspronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain. Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d).Animal Model:Male Wistar rats weighting 180-200 g Dosage:10 and 30 mg/kg Administration:s.c. Result:Induced c-Fos in medial paraventricular nucleus of hypothalamus. Treatment with 30 mg/kg ispronicline, but not 10 mg/kg, increased the number of c-Fos immunoreactive cells significantly as compared to controls within the medial parvocellular part of paraventricular nucleus (PVN).
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number252870-53-4
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Formula Weight234.34
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Molecular FormulaC14H22N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (426.73 mM; Ultrasonic )
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SMILESCN[C@@H](C)C\C=C\c1cncc(OC(C)C)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515(1):7-11.?
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