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VU 0365114
CAS No. 1208222-39-2
VU 0365114( —— )
Catalog No. M26505 CAS No. 1208222-39-2
VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
|
| 5MG | 80 | Get Quote |
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| 10MG | 113 | Get Quote |
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| 25MG | 209 | Get Quote |
|
| 50MG | 353 | Get Quote |
|
| 100MG | 530 | Get Quote |
|
| 500MG | 1152 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVU 0365114
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NoteResearch use only, not for human use.
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Brief DescriptionVU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).
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DescriptionVU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).
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In VitroVU 0365114 (10 μM) increases insulin secretion stimulated by ACh in human β-cells.VU 0365114 (10 μM) does not alter somatostatin secretion stimulated by ACh in human β-cells.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorCleavable
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Research Area——
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Indication——
Chemical Information
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CAS Number1208222-39-2
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Formula Weight397.353
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Molecular FormulaC22H14F3NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 77.5 mg/mL (195.04 m)
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SMILESFC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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