Emivirine

Research use only, not for human use.

Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor for human immunodeficiency virus type 1.

Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity.

Emivirine (EMV) is also specific for HIV-1 RT and was without effect on HIV-2.Emivirine (EMV) has no obvious toxicity for human healthy cells.:Cell Viability Assay Cell Line:Human bone marrow cells collected from normal healthy volunteers.Concentration:0, 0.1, 1, 10, or 100 μM.Incubation Time:14 days.Result:At concentrations of 0.1 to 10 μM, no effect on cell growth, lactic acid production, mitochondrial DNA synthesis, or mitochondrial structure was seen compared to what occurred with untreated HepG2 cells.

Tthe approximate lethal oral dose of Emivirine (EMV) for rats was ≥3 g/kg for males and 2.5 g/kg for females.Animal Model:Male Sprague-Dawley rats.Dosage:50 mg/kg.Administration:Gavage.Result:The oral absorption was 68%.

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Microbiology/Virology

HIV

HIV Protease

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149950-60-7

302.37

C17H22N2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (330.72 mM; Ultrasonic )

C(C1=C(C(C)C)C(=O)NC(=O)N1COCC)C2=CC=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years