Bicyclol( Bicyclol | SY 801 | SY-801 | SY801 )

Catalog No. M17171 CAS No. 118159-48-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Bicyclol
Note

Research use only, not for human use.
Brief Description

Bicyclol(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication.
Description

Bicyclol, also known as SY 801, is a hepatoprotective agent. Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Bicyclol promotes toll-like 2 receptor recruiting inosine 5'-monophosphate dehydrogenase II to exert its anti-inflammatory effect.
In Vitro

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In Vivo

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Synonyms

Bicyclol | SY 801 | SY-801 | SY801
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

HBV
Research Area

Infection
Indication

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CAS Number

118159-48-1
Formula Weight

390.34
Molecular Formula

C19H18O9
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 68 mg/mL. 174.21 mM
SMILES

COc1c2c(c(c(c1)CO)c1c3c(c(cc1C(=O)OC)OC)OCO3)OCO2
Chemical Name

5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester

1.Walsh, S.W., Y. Wang, and A. Killian, AA-2414, J Pharmacol Exp Ther, 1999. 290(1): p. 220-6.

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