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SKA-111
CAS No. 1369170-24-0
SKA-111( —— )
Catalog No. M34028 CAS No. 1369170-24-0
SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 162 | In Stock |
|
| 5MG | 147 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 504 | In Stock |
|
| 50MG | 712 | In Stock |
|
| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2000 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSKA-111
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NoteResearch use only, not for human use.
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Brief DescriptionSKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.
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DescriptionSKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.
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In Vitro——
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In VivoAnimal Model:Langendorff in rat hearts Dosage:1 μM Administration:Cardiac perfusion Result:Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1369170-24-0
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Formula Weight214.29
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Molecular FormulaC12H10N2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (466.66 mM; Ultrasonic )
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SMILESNC1=NC=2C=3C(C(C)=CC2S1)=CC=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. ?
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