BSH-IN-1( —— )

Catalog No. M32818 CAS No. 2553217-91-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BSH-IN-1
Note

Research use only, not for human use.
Brief Description

BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH).
Description

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.
In Vitro

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In Vivo

Animal Model:C57BL/6 miceDosage:10?mg/kg Administration:Single gavage Result:Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.
Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

——
Indication

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CAS Number

2553217-91-5
Formula Weight

408.59
Molecular Formula

C25H41FO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (61.19 mM; Ultrasonic (<80°C)
SMILES

[H][C@]1([C@@H](CCC(CF)=O)C)CC[C@]2([C@@]3([C@@H](C[C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H]
Chemical Name

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1. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases.Nat Chem Biol.?2020 Mar;16(3):318-326.?

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