BSH-IN-1
CAS No. 2553217-91-5
BSH-IN-1( —— )
Catalog No. M32818 CAS No. 2553217-91-5
BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 311 | In Stock |
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| 5MG | 282 | In Stock |
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| 10MG | 446 | In Stock |
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| 25MG | 738 | In Stock |
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| 50MG | 995 | In Stock |
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| 100MG | 1386 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBSH-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionBSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH).
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DescriptionBSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.
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In Vitro——
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In VivoAnimal Model:C57BL/6 miceDosage:10?mg/kg Administration:Single gavage Result:Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number2553217-91-5
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Formula Weight408.59
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Molecular FormulaC25H41FO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (61.19 mM; Ultrasonic (<80°C)
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SMILES[H][C@]1([C@@H](CCC(CF)=O)C)CC[C@]2([C@@]3([C@@H](C[C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases.Nat Chem Biol.?2020 Mar;16(3):318-326.?
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