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Hh-Ag1.5

CAS No. 612542-14-0

Hh-Ag1.5( —— )

Catalog No. M34022 CAS No. 612542-14-0

Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Hh-Ag1.5
  • Note
    Research use only, not for human use.
  • Brief Description
    Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo.
  • Description
    Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure.
  • In Vitro
    HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from non-injured liver in vitro. Hh-Ag1.5 competely binds to the Smo-containing membranes with the Ki value of 0.52 nM.The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog/Smoothened
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    612542-14-0
  • Formula Weight
    526.04
  • Molecular Formula
    C28H26ClF2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (95.05 mM; Ultrasonic )
  • SMILES
    CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1(2):8.?
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