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Folinic acid

CAS No. 58-05-9

Folinic acid( —— )

Catalog No. M33999 CAS No. 58-05-9

Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Folinic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
  • Description
    Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)Dosage:7.0 mg/kg Administration:Intraperitoneal injection; every second day; for 3 weeks Result:Following MTX administration appears to reverse this growth inhibition.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite | Antifolate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    58-05-9
  • Formula Weight
    473.44
  • Molecular Formula
    C20H23N7O7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (528.05 mM; Ultrasonic )
  • SMILES
    Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)N(C=O)c2c(=O)[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.?
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