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SR 2640 hydrochloride

CAS No. 146662-42-2

SR 2640 hydrochloride( —— )

Catalog No. M33931 CAS No. 146662-42-2

SR 2640 hydrochloride is a competitive antagonist of leukotriene D4 and E4 and can be used in studies about leukotrienes in human asthma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SR 2640 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SR 2640 hydrochloride is a competitive antagonist of leukotriene D4 and E4 and can be used in studies about leukotrienes in human asthma.
  • Description
    SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma.
  • In Vitro
    ——
  • In Vivo
    SR2640 inhibits the LTD 4-induced contractions of guinea-pig ileum in a concentration-dependent manner, with an IC50 of 3 nM.SR2640 (1 mg/kg; IV; single dosage) specifically prevents the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4.Animal Model:Guinea pigs (injected with LTD4 and LTE4)Dosage:1 mg/kg Administration:IV; single dosage Result:Specifically prevented the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Leukotriene Receptor
  • Recptor
    Leukotriene Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    146662-42-2
  • Formula Weight
    406.86
  • Molecular Formula
    C23H19ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (614.46 mM; Ultrasonic )
  • SMILES
    Cl.OC(=O)c1ccccc1Nc1cccc(OCc2ccc3ccccc3n2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ahnfelt-R?nne I, Kirstein D, Kaergaard-Nielsen C. A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur J Pharmacol. 1988;155(1-2):117-128.?
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