Ablukast

Research use only, not for human use.

Ablukast is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic.

Ablukast is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic.

Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation.

Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation. Animal Model:Female BALB/c mice Dosage:Concentrations of 0.1 , 0.5 , 1.0 and 5.0 % of Ablukast Administration:Applied to one of the pretreated ears 1 h after elicitation and at 24 h intervals on the following 4 days; three times daily Result:Effectively reduced DNFB-induced ear swelling.

Ro 23-3544

GPCR/G Protein

Leukotriene Receptor

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96566-25-5

498.572

C28H34O8

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (200.58 mM)

CCCc1c(O)c(ccc1OCCCCCOc1cc2OC(CCc2cc1C(C)=O)C(O)=O)C(C)=O

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(-20℃)

With Ice Pack

≥ 2 years