SANT 2( —— )

Catalog No. M33922 CAS No. 329196-48-7

SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anticancer activity for the study of prostate, pancreatic and breast cancer.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SANT 2
Note

Research use only, not for human use.
Brief Description

SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anticancer activity for the study of prostate, pancreatic and breast cancer.
Description

SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Hedgehog/Smoothened
Research Area

——
Indication

——

Chemical Information

CAS Number

329196-48-7
Formula Weight

479.96
Molecular Formula

C26H26ClN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (520.88 mM; Ultrasonic )
SMILES

O=C(NC=1C=CC(Cl)=C(C1)C2=NC=3C=CC=CC3N2)C4=CC(OCC)=C(OCC)C(OCC)=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54.?

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