LY 456236 hydrochloride

Research use only, not for human use.

LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.

LY456236 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC50 of 0.145 μM. LY456236 also inhibits EGFR with an IC50 of 0.91 μM.

Cell Proliferation Assay Cell Line:OCCM-30 cells Concentration:2 μM Incubation Time:30 min, followed by 72 h incubation with DHPG (HY-12598A) Result:Reduced DHPG-stimulated OCCM-30 proliferation.

Animal Model:DBA/2 mice and CD1 mice, seizure modelsDosage:3-100 mg/kgAdministration:IP, onceResult:Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice.Animal Model:Amygdala-kindled Sprague-Dawley rats Dosage:10, 30 and 60 mg/kg Administration:Oral, once Result:Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures.

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Angiogenesis

EGFR

EGFR | GluR

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338736-46-2

317.77

C16H16ClN3O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (786.73 mM; Ultrasonic (<60°C)

Cl.COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1

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(-20℃)

With Ice Pack

≥ 2 years