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LY 456236 hydrochloride
CAS No. 338736-46-2
LY 456236 hydrochloride( —— )
Catalog No. M33882 CAS No. 338736-46-2
LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 32 | In Stock |
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| 10MG | 51 | In Stock |
|
| 25MG | 111 | In Stock |
|
| 50MG | 178 | In Stock |
|
| 100MG | 256 | In Stock |
|
| 200MG | 356 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLY 456236 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.
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DescriptionLY456236 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC50 of 0.145 μM. LY456236 also inhibits EGFR with an IC50 of 0.91 μM.
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In VitroCell Proliferation Assay Cell Line:OCCM-30 cells Concentration:2 μM Incubation Time:30 min, followed by 72 h incubation with DHPG (HY-12598A) Result:Reduced DHPG-stimulated OCCM-30 proliferation.
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In VivoAnimal Model:DBA/2 mice and CD1 mice, seizure modelsDosage:3-100 mg/kgAdministration:IP, onceResult:Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice.Animal Model:Amygdala-kindled Sprague-Dawley rats Dosage:10, 30 and 60 mg/kg Administration:Oral, once Result:Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures.
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR | GluR
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Research Area——
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Indication——
Chemical Information
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CAS Number338736-46-2
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Formula Weight317.77
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Molecular FormulaC16H16ClN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (786.73 mM; Ultrasonic (<60°C)
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SMILESCl.COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ravikumar B, et al. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chem Biol. 2019 Nov 21;26(11):1608-1622.e6.?
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