Cart
sales@molnova.com
BC 11 hydrobromide
CAS No. 443776-49-6
BC 11 hydrobromide( —— )
Catalog No. M33833 CAS No. 443776-49-6
BC 11 hydrobromide is a selective TMPRSS2 and urokinase (uPA) inhibitor.BC-11 induces diminished mitochondrial activity, promotes reactive oxygen species production, and promotes apoptosis, and can be used in the study of breast cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 61 | In Stock |
|
| 10MG | 103 | In Stock |
|
| 25MG | 227 | In Stock |
|
| 50MG | 330 | In Stock |
|
| 100MG | 489 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBC 11 hydrobromide
-
NoteResearch use only, not for human use.
-
Brief DescriptionBC 11 hydrobromide is a selective TMPRSS2 and urokinase (uPA) inhibitor.BC-11 induces diminished mitochondrial activity, promotes reactive oxygen species production, and promotes apoptosis, and can be used in the study of breast cancer.
-
DescriptionBC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | ROS | Serine Protease
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number443776-49-6
-
Formula Weight290.97
-
Molecular FormulaC8H12BBrN2O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESBr.N=C(SCC1=CC=C(C=C1)B(O)O)N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371.?
molnova catalog
related products
-
HFY-4A
HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.
-
Se-Aspirin
Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-?B pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-?B (e.g., Bcl-xL, Mcl-1, and survivin).
-
Mepazine
Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.
