VTP50469
CAS No. 2169916-18-9
VTP50469( —— )
Catalog No. M23981 CAS No. 2169916-18-9
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 491 | In Stock |
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| 5MG | 353 | In Stock |
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| 10MG | 424 | In Stock |
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| 25MG | 592 | In Stock |
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| 50MG | 739 | In Stock |
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| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVTP50469
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NoteResearch use only, not for human use.
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Brief DescriptionVTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
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DescriptionVTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
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In Vitro——
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In VivoAnimal Model:Unconditioned immunodeficient (NSG) mice with MV4;11 cells Dosage:15 mg/kg, 30 mg/kg, and 60 mg/kg Administration:Oral administration; twice a day; for 28 days Result:Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|Menin-MLL interaction
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Research Area——
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Indication——
Chemical Information
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CAS Number2169916-18-9
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Formula Weight630.82
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Molecular FormulaC32H47FN6O4S
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (198.15 mM; Need ultrasonic)
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SMILESCC(C)N(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=CN=CN=C2N3CC4(C3)CCN(CC4)CC5CCC(CC5)NS(=O)(=O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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MY-1076
MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.
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Kinsenoside shows significant antihepatotoxic and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function it could promote the glucose tolerance of acute glucose increase in both diabetic and normal healthy rats.
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Scoulerine
Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
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