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VTP50469

CAS No. 2169916-18-9

VTP50469( —— )

Catalog No. M23981 CAS No. 2169916-18-9

VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 491 In Stock
5MG 353 In Stock
10MG 424 In Stock
25MG 592 In Stock
50MG 739 In Stock
100MG 995 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    VTP50469
  • Note
    Research use only, not for human use.
  • Brief Description
    VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
  • Description
    VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Unconditioned immunodeficient (NSG) mice with MV4;11 cells Dosage:15 mg/kg, 30 mg/kg, and 60 mg/kg Administration:Oral administration; twice a day; for 28 days Result:Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|Menin-MLL interaction
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2169916-18-9
  • Formula Weight
    630.82
  • Molecular Formula
    C32H47FN6O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (198.15 mM; Need ultrasonic)
  • SMILES
    CC(C)N(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=CN=CN=C2N3CC4(C3)CCN(CC4)CC5CCC(CC5)NS(=O)(=O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36(6):660-673.e11.
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