Anisodamine B( —— )

Catalog No. M33741 CAS No. 55869-99-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Anisodamine B
Note

Research use only, not for human use.
Brief Description

Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine.
Description

Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning.
In Vitro

Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.
In Vivo

Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%.Animal Model:LPS-Induced Shock Mice Dosage:50 mg/kg Administration:I.p.Result:Markedly decreased the mortality to 20%.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

AChR
Recptor

AChR
Research Area

——
Indication

——

CAS Number

55869-99-3
Formula Weight

305.37
Molecular Formula

C17H23NO4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 100 mg/mL (327.47 mM; )H2O : 20 mg/mL (65.49 mM; Ultrasonic)
SMILES

CN1[C@@H]2C[C@H](O)[C@H]1C[C@H](C2)OC(=O)[C@H](CO)c1ccccc1
Chemical Name

——

1. Eisenkraft A, et al. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016 Jun;173(11):1719-27.?

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