Oxotremorine sesquifumarate

Research use only, not for human use.

Oxotremorine sesquifumarate is a muscarinic receptor agonist.

Oxotremorine sesquifumarate is a muscarinic receptor agonist.(In Vitro):Oxotremorine (10.5 micron) produced a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.(In Vivo):Rats with signs of neuropathy were subjected to SCS applied in awake, freely moving condition. Oxotremorine was administered intrathecally. Tactile, cold and heat sensitivities were assessed by using von Frey filaments, cold spray and focused radiant heat, respectively. Oxotremorine i.t. dose-dependently suppressed the tactile hypersensitivity. SCS markedly increased withdrawal thresholds (WTs), withdrawal latencies and cold scores.

Oxotremorine (10.5 μM) produces a paralytic effect on twitch responses of rat diaphragm in vitro to direct and indirect stimulation.

In rats with sciatic nerve injuries, Oxotremorine (10, 5, 21 μg; 10 μL) i.t. dose-dependently suppresses the tactile hypersensitivity.

——

Cell Cycle/DNA Damage

AChR

——

——

——

17360-35-9

760.794

C36H48N4O14

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (328.60 mM)

OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.O=C1CCCN1CC#CCN1CCCC1.O=C1CCCN1CC#CCN1CCCC1

——

(-20℃)

With Ice Pack

≥ 2 years