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9-cis-Retinoic Acid

CAS No. 5300-03-8

9-cis-Retinoic Acid( —— )

Catalog No. M33736 CAS No. 5300-03-8

9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 188 In Stock
25MG 364 In Stock
50MG 569 In Stock
100MG 894 In Stock
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Biological Information

  • Product Name
    9-cis-Retinoic Acid
  • Note
    Research use only, not for human use.
  • Brief Description
    9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.
  • Description
    9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and hasanticancer, anti-inflammatory and neuroprotection activities.
  • In Vitro
    Cell Proliferation Assay Cell Line:CA 9-22 and NA cells Concentration:1 μM, 10 μM Incubation Time:0 day, 1 day, 3 days, 5 days Result:Significantly decreased proliferation.
  • In Vivo
    Animal Model:Male C57BL/6J mice (6-8 weeks; 19-22 g) treatment with bile duct ligated Dosage:1 mg/kg Administration:Intravenous injection; daily; for 10 days Result:Significantly decreased the serum ALT and AST level, alleviated hepatic necrosis.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    5300-03-8
  • Formula Weight
    300.44
  • Molecular Formula
    C20H28O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (83.21 mM; Ultrasonic )
  • SMILES
    C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080.?
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