Amlodipine maleate( —— )

Catalog No. M33714 CAS No. 88150-47-4

Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	44	In Stock
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500MG	39	In Stock
1G	63	In Stock

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Biological Information

Product Name

Amlodipine maleate
Note

Research use only, not for human use.
Brief Description

Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.
Description

Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
In Vitro

Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.
In Vivo

Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.Animal Model:ATP2B1loxP/loxP mice Dosage:5 mg/kg/day Administration:Subcutaneously implanted osmotic pump for 2 weeksResult:Significantly decreased the blood pressure.
Synonyms

——
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel
Research Area

——
Indication

——

Chemical Information

CAS Number

88150-47-4
Formula Weight

524.95
Molecular Formula

C24H29ClN2O9
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 120 mg/mL (228.59 mM; Ultrasonic )
SMILES

C(=C\C(O)=O)\C(O)=O.C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.?

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