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Ro 90-7501
CAS No. 293762-45-5
Ro 90-7501( —— )
Catalog No. M33482 CAS No. 293762-45-5
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 258 | In Stock |
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| 50MG | 431 | In Stock |
|
| 100MG | 732 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRo 90-7501
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NoteResearch use only, not for human use.
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Brief DescriptionRo 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitizer for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.
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DescriptionRo 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner.Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
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In Vitro——
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In VivoAnimal Model:Female BALB/c nude mice (8-week-old) with HeLa cells underirradiation Dosage:5 μg/g Administration:Intraperitoneal injection; daily; for 21 days Result:Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetATM/ATR
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RecptorATM/ATR | Apoptosis | Phosphatase | Gamma-secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number293762-45-5
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Formula Weight340.38
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Molecular FormulaC20H16N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (122.42 mM; Ultrasonic )
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SMILESNC1=CC=C(C=C1)C1=NC2=C(N1)C=C(C=C2)C1=NC2=C(N1)C=C(N)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810.?
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