Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - ATM/ATR - KU-60019

KU-60019

CAS No. 925701-46-8

KU-60019( KU60019 | KU 60019 )

Catalog No. M16633 CAS No. 925701-46-8

KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 86 In Stock
5MG 70 In Stock
10MG 102 In Stock
25MG 186 In Stock
50MG 304 In Stock
100MG 508 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    KU-60019
  • Note
    Research use only, not for human use.
  • Brief Description
    KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR.
  • Description
    KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3 nM, 270- and 1,600-fold selectivity over DNA-PKcs and ATR; blocks radiation-induced phosphorylation of key ATM targets in human glioma cells, which is 10-fold more effective than KU-55933, reduces basal S473 AKT phosphorylation and inhibits glioma cell migration and invasion in vitro; preferentially sensitizes p53-mutant glioma to ionizing radiation in orthotopic xenograft models of GBM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KU60019 | KU 60019
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ATM/ATR
  • Recptor
    ATM/ATR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    925701-46-8
  • Formula Weight
    547.6651
  • Molecular Formula
    C30H33N3O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6
  • Chemical Name
    4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Golding SE, et al. Mol Cancer Ther. 2009 Oct;8(10):2894-902. 2. Gamper AM, et al. J Biol Chem. 2012 Apr 6;287(15):12445-54. 3. Biddlestone-Thorpe L, et al. Clin Cancer Res. 2013 Jun 15;19(12):3189-200. 4. Golding SE, et al. Cell Cycle. 2012 Mar 15;11(6):1167-73.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • KU 59403

    KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.

  • GSK 635416A

    GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.

  • CBP-93872

    A potent G2 checkpoint inhibitor that specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint.

Sign In Join Free