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MK-0674
CAS No. 887781-62-6
MK-0674( —— )
Catalog No. M33431 CAS No. 887781-62-6
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 644 | In Stock |
|
| 10MG | 872 | In Stock |
|
| 25MG | 1292 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-0674
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NoteResearch use only, not for human use.
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Brief DescriptionMK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
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DescriptionMK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
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In VitroMK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetCysteine Protease
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RecptorCysteine Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number887781-62-6
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Formula Weight527.5
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Molecular FormulaC26H27F6N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C([C@@H](N[C@H]([C@](F)(F)F)C1=CC=C(C=C1)C2=CC=C([C@H](C(F)F)O)C=C2)CC(C)(C)F)=O)C3(C#N)CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.?
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