Aurantiamide acetate

Research use only, not for human use.

Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.

Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases.(In Vitro):Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively. (In Vivo):Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.

Aurantiamide acetate inhibits cathepsin L (3.4.22.15) and cathepsin B (3.4.22.1) with IC50?of 12 μM and 49 μM, respectiveiy.

——

Asperglaucide

Proteasome/Ubiquitin

Cysteine Protease

Cysteine Protease

——

——

56121-42-7

444.52

C27H28N2O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (112.48 mM)

CC(OC[C@H](Cc1ccccc1)NC([C@H](Cc1ccccc1)NC(c1ccccc1)=O)=O)=O

——

(-20℃)

With Ice Pack

≥ 2 years