VBY-825

Research use only, not for human use.

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.(In Vitro):VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse.(In Vivo):10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

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Proteasome/Ubiquitin

Cysteine Protease

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1310340-58-9

535.55

C23H29F4N3O5S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (233.40 mM)

CC[C@H](NC(=O)[C@H](CS(=O)(=O)CC1CC1)N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)C(=O)NC1CC1

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(-20℃)

With Ice Pack

≥ 2 years