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GSK319347A
CAS No. 862812-98-4
GSK319347A( —— )
Catalog No. M33384 CAS No. 862812-98-4
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 102 | Get Quote |
|
| 5MG | 147 | Get Quote |
|
| 10MG | 255 | Get Quote |
|
| 25MG | 518 | Get Quote |
|
| 50MG | 881 | Get Quote |
|
| 100MG | 1152 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK319347A
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NoteResearch use only, not for human use.
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Brief DescriptionGSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
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DescriptionGSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.
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In VitroGSK319347A (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIκB/IKK
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Research Area——
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Indication——
Chemical Information
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CAS Number862812-98-4
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Formula Weight469.53
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Molecular FormulaC22H19N3O5S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 45 mg/mL (95.84 mM; Ultrasonic )
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SMILESCOc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johannes JW, et al. Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1138-43.?
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