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EHT 1610
CAS No. 1425945-60-3
EHT 1610( —— )
Catalog No. M33348 CAS No. 1425945-60-3
EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 212 | In Stock |
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| 10MG | 316 | In Stock |
|
| 25MG | 511 | In Stock |
|
| 50MG | 681 | In Stock |
|
| 100MG | 921 | In Stock |
|
| 200MG | 1237 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEHT 1610
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NoteResearch use only, not for human use.
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Brief DescriptionEHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.
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DescriptionEHT 1610 is a potent inhibitor of DYRK, with IC50s of 0.36 nM (DYRK1A), 0.59 nM (DYRK1B), respectively. EHT 1610 exhibits antileukemia effect, regulates cell cycle and induces cell apoptosis-.
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In VitroWestern Blot Analysis Cell Line:MHH-CALL-4 cells Concentration:0, 2.5, 5, 10 μM Incubation Time:4, 5 hours Result:Reduced p-cyclin D3 (Thr283), and p-FOXO1 protein level in a dose-dependent manner.
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In VivoAnimal Model:Xenograft models of B-ALL in mice (12-14 weeks old)Dosage:20 mg/kg Administration:Intraperitoneal injection; twice a day, 5 days on, 2 days off; 3 weeks Result:Reduced leukemic burden by approximately 8% and conferred a modest survival advantage.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetTyrosinase
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RecptorTyrosinase | NF-κB | GSK-3 | DYRK | CDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1425945-60-3
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Formula Weight383.4
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Molecular FormulaC18H14FN5O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (13.04 mM; Ultrasonic )
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SMILESCOC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chaikuad A, et al. An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases. J Med Chem. 2016 Nov 23;59(22):10315-10321.?
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