Chloroquinoxaline sulfonamide

Research use only, not for human use.

Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer.

Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.

The Chloroquinoxaline sulfonamide IC50?for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links.Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used.Cell Proliferation Assay Cell Line:B16 murine melanoma cells Concentration:10 μM, 100 μM, 1 mM Incubation Time:24, 48, 72 hours Result:Inhibited proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) were used.

——

——

Cell Cycle/DNA Damage

Topoisomerase

Topoisomerase

——

——

97919-22-7

334.78

C14H11ClN4O2S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (373.38 mM; Ultrasonic )

Nc1ccc(cc1)S(=O)(=O)Nc1cnc2c(Cl)cccc2n1

——

(-20℃)

With Ice Pack

≥ 2 years