Cart
sales@molnova.com
Tubulin inhibitor 35
CAS No. 2247047-77-2
Tubulin inhibitor 35( —— )
Catalog No. M36970 CAS No. 2247047-77-2
Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 120 | In Stock |
|
| 10MG | 176 | In Stock |
|
| 25MG | 282 | In Stock |
|
| 50MG | 426 | In Stock |
|
| 100MG | 621 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2186 | In Stock |
|
| 1G | 3004 | In Stock |
|
Biological Information
-
Product NameTubulin inhibitor 35
-
NoteResearch use only, not for human use.
-
Brief DescriptionTubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migration and invasion of MGC-803 and RKO cell lines, interrupts the cell cycle and induces apoptosis.
-
DescriptionTubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines).
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetTopoisomerase
-
RecptorTopoisomerase | Microtubule Associated | Apoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2247047-77-2
-
Formula Weight331.41
-
Molecular FormulaC21H21N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C1C=2C=CC=CC2N(CCC)C3C=4NC=5C=CC=CC5C4CCN13
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Deng J, et al. N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents. Eur J Med Chem. 2023 Jul 5;255:115366.?
molnova catalog
related products
-
Voreloxin
A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II.
-
Irinotecan Hydrochlo...
Irinotecan Hcl(CPT-11 Hcl) prevents DNA from unwinding by inhibition of topoisomerase 1.
-
Pyronaridine tetraph...
Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.
