Cart
sales@molnova.com
Butyrolactone 3
CAS No. 778649-18-6
Butyrolactone 3( —— )
Catalog No. M33299 CAS No. 778649-18-6
Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 145 | In Stock |
|
| 10MG | 235 | In Stock |
|
| 25MG | 471 | In Stock |
|
| 50MG | 770 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameButyrolactone 3
-
NoteResearch use only, not for human use.
-
Brief DescriptionButyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
-
DescriptionButyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases.
-
In VitroWestern Blot Analysis Cell Line:RCH-ACV Concentration:50, 100, 200 μM Incubation Time:16 h Result:Decreased the protein levels of E2A-PBX1 and E2A in a dose-dependent manner.Reduced Wnt16 and GCN5 protein levels.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorEpigenetic Reader Domain | Antibacterial
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number778649-18-6
-
Formula Weight184.19
-
Molecular FormulaC9H12O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (542.92 mM; Ultrasonic )
-
SMILESCCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6?
molnova catalog
related products
-
CBP-IN-1
CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
-
BRD7-IN-1
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively .
-
FHD-286
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.
