Cart
sales@molnova.com
Butyrolactone 3
CAS No. 778649-18-6
Butyrolactone 3( —— )
Catalog No. M33299 CAS No. 778649-18-6
Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 145 | In Stock |
|
| 10MG | 235 | In Stock |
|
| 25MG | 471 | In Stock |
|
| 50MG | 770 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameButyrolactone 3
-
NoteResearch use only, not for human use.
-
Brief DescriptionButyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
-
DescriptionButyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases.
-
In VitroWestern Blot Analysis Cell Line:RCH-ACV Concentration:50, 100, 200 μM Incubation Time:16 h Result:Decreased the protein levels of E2A-PBX1 and E2A in a dose-dependent manner.Reduced Wnt16 and GCN5 protein levels.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorEpigenetic Reader Domain | Antibacterial
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number778649-18-6
-
Formula Weight184.19
-
Molecular FormulaC9H12O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (542.92 mM; Ultrasonic )
-
SMILESCCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6?
molnova catalog
related products
-
Trotabresib
Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.
-
AW68
AW68 is a potential small molecule BRD4 inhibitor that prevents and treats BRD4-related diseases and can be used in cancer research.
-
XD14
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively).
