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Butyrolactone 3

CAS No. 778649-18-6

Butyrolactone 3( —— )

Catalog No. M33299 CAS No. 778649-18-6

Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Butyrolactone 3
  • Note
    Research use only, not for human use.
  • Brief Description
    Butyrolactone 3 (MB-3) is a histone acetyltransferase Gcn5 inhibitor with a weak affinity for CBP.Butyrolactone 3 has antimicrobial activity and has been used in cancer, metabolic and neurological disorders.
  • Description
    Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases.
  • In Vitro
    Western Blot Analysis Cell Line:RCH-ACV Concentration:50, 100, 200 μM Incubation Time:16 h Result:Decreased the protein levels of E2A-PBX1 and E2A in a dose-dependent manner.Reduced Wnt16 and GCN5 protein levels.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Epigenetic Reader Domain | Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    778649-18-6
  • Formula Weight
    184.19
  • Molecular Formula
    C9H12O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (542.92 mM; Ultrasonic )
  • SMILES
    CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6?
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