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BRD7-IN-1
CAS No. 2448414-48-8
BRD7-IN-1( —— )
Catalog No. M33545 CAS No. 2448414-48-8
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 240 | In Stock |
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| 2MG | 140 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 353 | In Stock |
|
| 25MG | 635 | In Stock |
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| 50MG | 923 | In Stock |
|
| 100MG | 1283 | In Stock |
|
| 200MG | 1748 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBRD7-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionBRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 via linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively .
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DescriptionBRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEpigenetic Reader Domain
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Research Area——
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Indication——
Chemical Information
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CAS Number2448414-48-8
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Formula Weight467.39
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Molecular FormulaC22H28Cl2N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (213.95 mM; Ultrasonic)DMSO : 30 mg/mL (64.19 mM; Ultrasonic )
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SMILESCl.Cl.COc1cc(cc(OC)c1CN1CCNCC1)-c1cn(C)c(=O)c2cnccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62?
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