Cart
sales@molnova.com
Home - Products - PI3K/Akt/mTOR signaling - PI3K - Dactolisib Tosylate

Dactolisib Tosylate

CAS No. 1028385-32-1

Dactolisib Tosylate( —— )

Catalog No. M33289 CAS No. 1028385-32-1

Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor targeting PI3K and mTOR, with IC50 values of 4, 75, 7, and 5 nM for PI3Kα, β, γ, and δ, respectively. It also inhibits mTORC1 and mTORC2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 39 Get Quote
50MG 54 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Dactolisib Tosylate
  • Note
    Research use only, not for human use.
  • Brief Description
    Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor targeting PI3K and mTOR, with IC50 values of 4, 75, 7, and 5 nM for PI3Kα, β, γ, and δ, respectively. It also inhibits mTORC1 and mTORC2.
  • Description
    Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3K | mTOR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1028385-32-1
  • Formula Weight
    641.74
  • Molecular Formula
    C37H31N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 34 mg/mL (52.98 mM )H2O : < 0.1 mg/mL (insoluble)
  • SMILES
    Cc1ccc(cc1)S(O)(=O)=O.Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Maira SM, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7(7), 1851-1863.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GSK1016790A

    GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.

  • Tectorigenin

    Tectorigenin is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing.

  • PQR-530

    PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor.

Sign In Join Free