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THZ-P1-2
CAS No. 2058075-45-7
THZ-P1-2( —— )
Catalog No. M35120 CAS No. 2058075-45-7
THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 182 | In Stock |
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| 2MG | 93 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 217 | In Stock |
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| 25MG | 350 | In Stock |
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| 50MG | 483 | In Stock |
|
| 100MG | 677 | In Stock |
|
| 200MG | 914 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTHZ-P1-2
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NoteResearch use only, not for human use.
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Brief DescriptionTHZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.
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DescriptionTHZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines.
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In VitroCell Proliferation Assay Cell Line:THP1, SEMK2, OCI/AML-2, HL60, SKM1, NOMO1 cells Concentration:10-100000 nM Incubation Time:72 hours Result:Showed anti-proliferative activity in all six AML/ALL cell lines with IC50 values ranging from 0.87 to 3.95 μM.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number2058075-45-7
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Formula Weight531.61
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Molecular FormulaC31H29N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (188.11 mM; Ultrasonic )
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SMILESCN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27(5):525‐537.e6.?
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