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BDP9066
CAS No. 2226507-04-4
BDP9066( —— )
Catalog No. M33284 CAS No. 2226507-04-4
BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 128 | In Stock |
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| 5MG | 117 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 432 | In Stock |
|
| 50MG | 732 | In Stock |
|
| 100MG | 1265 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2530 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBDP9066
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NoteResearch use only, not for human use.
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Brief DescriptionBDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.
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DescriptionBDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.
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In VitroBDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion.
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In VivoBDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research Area——
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Indication——
Chemical Information
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CAS Number2226507-04-4
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Formula Weight348.44
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Molecular FormulaC20H24N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (28.70 mM; Ultrasonic )
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SMILESC1CC[C@@]2(CCCN(C2)c2cc[nH]c3ncc(-c4ccncn4)c23)NC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Unbekandt M, et al. Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res. 2018 Apr 15;78(8):2096-2114.?
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