Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).Ripasudil shows less potent inhibitory activities against CaMKIIα, PKACα, and PKC (IC50s: 370 nM, 2.1 μM and 27 μM) .

BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM 50 nM 10 nM and 100 nM for ROCK1 ROCK2 MRCKα and MRCKβ respectively.)

ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC, with potential applications in cardiac, proliferative, and neurodegenerative disease research.