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Azido-PEG1-amine
CAS No. 464190-91-8
Azido-PEG1-amine( —— )
Catalog No. M33279 CAS No. 464190-91-8
Azido-PEG1-amine is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 30 | In Stock |
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| 25MG | 48 | In Stock |
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| 50MG | 68 | In Stock |
|
| 100MG | 99 | In Stock |
|
| 200MG | 157 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAzido-PEG1-amine
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NoteResearch use only, not for human use.
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Brief DescriptionAzido-PEG1-amine is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.
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DescriptionAzido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number464190-91-8
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Formula Weight130.15
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Molecular FormulaC4H10N4O
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Purity>98% (HPLC)
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Solubility——
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SMILES[N-]=[N+]=NCCOCCN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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GSK983
GSK983 (GSK-983) is a potent, cell penetrant PCAF/GCN5 PROTAC, induces concentration-dependent degradation of PCAF and GCN5 in THP1 cells with DC50 value of 1.5 nM and 3 nM, respectively.
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Amino-PEG11-amine
Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.
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Biotin-PEG3-acid
Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.Biotin-PEG3-acid is a heterobiofunctional biotin PEG derivative containing a carboxylic acid group. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule.
