QCA570( QCA 570 | QCA-570 )

Catalog No. M13519 CAS No. 2207569-08-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

QCA570
Note

Research use only, not for human use.
Brief Description

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level.
Description

QCA570 is a novel, highly potent efficacious BET degrader (PROTAC); effectively induces degradation of BET proteins and inhibits cell growth in human acute leukemia cell lines at pM level; inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively; causes complete and durable tumor regression in leukemia xenograft models in mice.
In Vitro

QCA570 is an extremely potent and highly efficacious BET degrader, capable of degrading BET proteins at low picomolar (pM) concentrations in leukemia cells. QCA570 inhibits cell growth in MV4;11, MOLM-13, and RS4;11 cell lines with IC50 values of 8.3, 62, and 32 pM, respectively. QCA570 is the most potent and efficacious BET degrader reported to date.
In Vivo

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Synonyms

QCA 570 | QCA-570
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

2207569-08-0
Formula Weight

695.798
Molecular Formula

C39H33N7O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 40 mg/mL (57.49 mM)
SMILES

O=C(C(N(CC1=C2C=CC=C1C#CCCCN3N=CC(C#CC(S4)=C(CC5=CC=CC=C5)C6=C4N7C(COC6)=NN=C7C)=C3)C2=O)CC8)NC8=O
Chemical Name

3-(4-(5-(4-((3-Benzyl-9-methyl-4H,6H-thieno[2,3-e][1,2,4]-triazolo[3,4-c][1,4]oxazepin-2-yl)ethynyl)-1H-pyrazol-1-yl)pent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

1. Qin C, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00506.

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