Compound 48/80 trihydrochloride

Research use only, not for human use.

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde produced via a condensation reaction.

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .

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Animal Model:7-week-old Wistar male rats (fasted for 24 hours) Dosage:0.75 mg/kg Administration:Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result:Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.

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Metabolic Enzyme/Protease

Phospholipase

Phospholipase

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848035-21-2

629.1

C32H48Cl3N3O3

>98% (HPLC)

In Vitro:?H2O : 25 mg/mL (39.74 mM; Ultrasonic) DMSO : 10 mg/mL (15.90 mM; Ultrasonic (<60°C)

Cl.Cl.Cl.CNCCc1ccc(OC)c(Cc2cc(CCNC)cc(Cc3cc(CCNC)ccc3OC)c2OC)c1

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(-20℃)

With Ice Pack

≥ 2 years