PF 5212372( PLA-950 | ZPL-521 | ZPL 5212372 )

Catalog No. M16579 CAS No. 916136-25-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PF 5212372
Note

Research use only, not for human use.
Brief Description

PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM.
Description

PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM; inhibits PGD2 and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells with IC50 of 0.29 and 0.45 nM, respectively; inhibits ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (IC50 2.6, 2.6, and 4.0 nM, respectively); significantly inhibits AMP-induced contraction of human bronchi.Dermatitis Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

PLA-950 | ZPL-521 | ZPL 5212372
Pathway

Metabolic Enzyme/Protease
Target

Phospholipase
Recptor

Phospholipase
Research Area

Inflammation/Immunology
Indication

Dermatitis

CAS Number

916136-25-9
Formula Weight

823.35
Molecular Formula

C42H38ClF3N2O6S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

4-[[2-[5-Chloro-1-(diphenylmethyl)-2-[2-[[[[2-(trifluoromethyl)phenyl]methyl]sulfonyl]amino]ethyl]-1H-indol-3-yl]ethyl]sulfonyl]benzenepropanoic acid

1. Hewson CA, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65. 2. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413.

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