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VU533
CAS No. 923417-09-8
VU533( —— )
Catalog No. M36992 CAS No. 923417-09-8
VU533 (Nape-Pld activator) is a NAPE-PLD activator with an EC50 value of 0.30 μM.VU533 enhances NAPE-PLD activity and increases macrophage cytosolic burial.VU533 may be used in diseases associated with cardiometabolism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
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| 5MG | 56 | In Stock |
|
| 10MG | 93 | In Stock |
|
| 25MG | 187 | In Stock |
|
| 50MG | 300 | In Stock |
|
| 100MG | 429 | In Stock |
|
| 200MG | 594 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU533
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NoteResearch use only, not for human use.
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Brief DescriptionVU533 (Nape-Pld activator) is a NAPE-PLD activator with an EC50 value of 0.30 μM.VU533 enhances NAPE-PLD activity and increases macrophage cytosolic burial.VU533 may be used in diseases associated with cardiometabolism.
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DescriptionAPE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 μM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research.
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In VitroCell Cytotoxicity Assay Cell Line:RAW264.7, HepG2 Concentration:0.1-30 μM Incubation Time:24 h Result:Showed no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells.Cell Autophagy Assay Cell Line:BMDM Concentration:10 μM Incubation Time:6 h Result:Enhanced efferocytosis compared to vehicle treated BMDM at 10μM.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPhospholipase
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Research Area——
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Indication——
Chemical Information
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CAS Number923417-09-8
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Formula Weight447.55
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Molecular FormulaC21H22FN3O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (279.30 mM; Ultrasonic (<60°C)
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SMILESCC1=CC=C(C)C2=C1SC(NC(=O)C1CCN(CC1)S(=O)(=O)C1=CC=C(F)C=C1)=N2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904.?
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