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TTA-Q6

CAS No. 910484-28-5

TTA-Q6( —— )

Catalog No. M33156 CAS No. 910484-28-5

TTA-Q6, a selective T-type Ca2+ channel antagonist, exhibits potential antitumor and immunomodulatory activities for treating neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cells, thereby inducing intracellular calcium deficiency and endoplasmic reticulum (ER) stress.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TTA-Q6
  • Note
    Research use only, not for human use.
  • Brief Description
    TTA-Q6, a selective T-type Ca2+ channel antagonist, exhibits potential antitumor and immunomodulatory activities for treating neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cells, thereby inducing intracellular calcium deficiency and endoplasmic reticulum (ER) stress.
  • Description
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, which can be used in the research of neurological disease.
  • In Vitro
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, with 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    910484-28-5
  • Formula Weight
    405.8
  • Molecular Formula
    C20H15ClF3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (308.03 mM; Ultrasonic )
  • SMILES
    FC(F)(F)CN1C(=O)Nc2ccc(Cl)cc2[C@]1(C1CC1)c1ccc(cc1)C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schlegel KA, et al. Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52.?
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