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Home - Products - GPCR/G Protein - Calcium Channel - Z-944

Z-944

CAS No. 1199236-64-0

Z-944( Z944 )

Catalog No. M10714 CAS No. 1199236-64-0

Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 120 In Stock
5MG 107 In Stock
10MG 180 In Stock
25MG 359 In Stock
50MG 519 In Stock
100MG 742 In Stock
200MG 1014 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Z-944
  • Note
    Research use only, not for human use.
  • Brief Description
    Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
  • Description
    Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels; displays 70 times more potent for T-type blockade than for blockade of the N-type channel (IC50=11 uM); potently suppress seizure activity and attenuates burst firing of thalamic reticular nucleus neurons in the GAERS model of absence epilepsy; restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.Pain Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Z944
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1199236-64-0
  • Formula Weight
    383.89
  • Molecular Formula
    C19H27ClFN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (130.25 mM)
  • SMILES
    O=C(NCC1CCN(CC(NC(C)(C)C)=O)CC1)C2=CC(F)=CC(Cl)=C2
  • Chemical Name
    N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tringham E, et al. Sci Transl Med. 2012 Feb 15;4(121):121ra19. 2. Casillas-Espinosa PM, et al. PLoS One. 2015 Aug 14;10(8):e0130012. 3. LeBlanc BW, et al. Pain. 2016 Jan;157(1):255-63.
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