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(R)-CR8 trihydrochloride

CAS No. 1786438-30-9

(R)-CR8 trihydrochloride( —— )

Catalog No. M33088 CAS No. 1786438-30-9

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 64 In Stock
2MG 33 In Stock
5MG 53 In Stock
10MG 81 In Stock
25MG 147 In Stock
50MG 217 In Stock
100MG 305 In Stock
200MG 455 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    (R)-CR8 trihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    (R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.
  • Description
    (R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K.
  • In Vitro
    Apoptosis Analysis Cell Line:SH-SY5Y cell line Concentration:0.1, 1, 10, 100 μM Incubation Time:24 hours Result:Reduced cell survival in a dose-dependent manner.
  • In Vivo
    Animal Model:Adult (10 to 12 weeks old) male Sprague-Dawley rats (310 to 330?g) Dosage:5?mg/Kg Administration:i.p.Result:Resulted in a significant reduction in lesion size.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1786438-30-9
  • Formula Weight
    540.92
  • Molecular Formula
    C24H32Cl3N7O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (92.44 mM; Ultrasonic )
  • SMILES
    Cl.Cl.Cl.CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccn2)c2ncn(C(C)C)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807.?
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