PD 90780( —— )

Catalog No. M33057 CAS No. 77422-99-2

PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	126	In Stock
5MG	116	In Stock
10MG	187	In Stock
25MG	377	In Stock
50MG	548	In Stock
100MG	784	In Stock
200MG	Get Quote	In Stock
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Biological Information

Product Name

PD 90780
Note

Research use only, not for human use.
Brief Description

PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
Description

PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
In Vitro

PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR.PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR.PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM.PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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Chemical Information

CAS Number

77422-99-2
Formula Weight

362.34
Molecular Formula

C19H14N4O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 31.25 mg/mL (86.24 mM; Ultrasonic (<60°C)
SMILES

Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J ?

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