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Tubulin inhibitor 8
CAS No. 1309925-39-0
Tubulin inhibitor 8( —— )
Catalog No. M33157 CAS No. 1309925-39-0
Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 276 | In Stock |
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| 5MG | 331 | In Stock |
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| 10MG | 451 | In Stock |
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| 25MG | 634 | In Stock |
|
| 50MG | 825 | In Stock |
|
| 100MG | 1135 | In Stock |
|
| 200MG | 1516 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTubulin inhibitor 8
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NoteResearch use only, not for human use.
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Brief DescriptionTubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.
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DescriptionTubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM.
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In VitroTubulin inhibitor 8 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms.Tubulin inhibitor 8 shows excellent antiproliferative potencies with IC50s of 15, 6, 8, 2, 8, 6, and 9 nM for NCIH460, SKOV3, BT549, 451LU, SW480, COLO-205, and DLD-1 tumor cell lines, recpectively.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated
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Research Area——
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Indication——
Chemical Information
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CAS Number1309925-39-0
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Formula Weight342.35
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Molecular FormulaC21H14N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=O)(N1C=2C(OC=3C1=CC=CC3)=CC(C#N)=CC2)C4=CC=C(OC)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.?
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