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GSK205

CAS No. 1263068-83-2

GSK205( —— )

Catalog No. M32950 CAS No. 1263068-83-2

GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 157 In Stock
5MG 148 In Stock
10MG 235 In Stock
25MG 519 In Stock
50MG 830 In Stock
100MG 1330 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GSK205
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.
  • Description
    GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibiting TRPV4-mediated Ca2+ influx.
  • In Vitro
    RT-PCR Cell Line:T3-F442A adipocytes Concentration:5 μM Incubation Time:4 days Result:Resulted in increased expression of thermogenic genes and is also accompanied by a decrease in the proinflammatory gene program.
  • In Vivo
    Animal Model:Male C57BL/6J mice with high-fat dietDosage:10 mg/kg Administration:Intraperitoneal injection; twice daily; for 7 days Result:Caused a reduced expression of the proinflammatory chemokines, macrophage marker and Tnfa in the EPI fat. Significantly improved glucose tolerance in diet-induced obese (DIO) mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel | TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1263068-83-2
  • Formula Weight
    481.45
  • Molecular Formula
    C24H25BrN4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (519.26 mM; Ultrasonic )
  • SMILES
    Br.CN(CCc1ccc(Nc2ncc(s2)-c2cccnc2)cc1)Cc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ye L, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28;151(1):96-110.?
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