diABZI STING agonist-1 (Tautomerism)

Research use only, not for human use.

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist,with EC50s of 130, 186 nM for human and mouse, respectively.

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested.

diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo.diABZI STING agonist-1 (Tautomerism) (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/ml).diABZI STING agonist-1 (Tautomerism) (intravenous injection; 1.5 mg/kg; 43 days) results in significant tumour growth inhibition and significantly improves survival (P?

——

Immunology/Inflammation

STING

STING

——

——

2138498-18-5

849.94

C42H51N13O7

>98% (HPLC)

——

C(/C=C/CN1C=2C(N=C1NC(=O)C=3N(CC)N=C(C)C3)=CC(C(N)=O)=CC2OC)N4C=5C(N=C4NC(=O)C=6N(CC)N=C(C)C6)=CC(C(N)=O)=CC5OCCCN7CCOCC7

——

(-20℃)

With Ice Pack

≥ 2 years